A study published by researchers at the Albert Einstein School of Medicine at Yeshiva University showed that intestinal bacteria play a crucial role in maintaining the integrity of the intestinal wall during food digestion.
The study involves the gut microbiome, which contains about 100 trillion bacteria, and the promotion or prevention of the effects of these microbes is an emerging field. Scientists at Einstein College of Medicine found that a specific bacterial byproduct has a crucial role in the intestinal tract. It is used to maintain the intestinal epithelial single cells that keep enteric bacteria and toxins in the intestine and will not be absorbed into the human body. Some diseases are caused by the breakdown of the intestinal epithelium.
"These bacteria and their metabolites affect the integrity of the intestinal epithelial cells, but how they work is not yet known," said Dr. Sridhar Mani, MD. Mani and his colleagues suspect that bacterial metabolites bind to receptors (PXRs) of intestinal epithelial cells to activate proteins and exert their effects. In a series of mouse experiments, the researchers found that a metabolite known as å²å“š3-propionic acid (IPA), through the activation of PXR, helps digestion and enhances the barrier function of the intestinal epithelium and prevents inflammation. More specifically, activation of PXR inhibits the production of TNF-[alpha], while enhancing binding proteins between adjacent intestinal epithelial cells.
"With the addition of IPA-producing bacteria or direct management of IPA, we may be able to prevent or treat inflammatory diseases caused by damage to the intestinal epithelium," said Dr. Mani. "Such a strategy can also be tried on some other forms of health issues including liver disease, diabetes, asthma, allergies, obesity and heart disease." Now Mani's team is developing new probiotics that are designed to interact via PXR Role, restore the barrier function of intestinal epithelial cells.
Hydraulic Cable Puller-tensioner
The hydraulic puller-tensioner can be used either as a puller or as a hydraulic tensioner in tension stringing operations. According to different models, it is possible to string from one or two or bundled conductors at the same time. The bull-wheel grooves consist of high resistance interchangeable nylon sectors or of wear-proof heat and chemically treated steel. The puller-tensioner is used for tension stretching and reverse pulling of double split conductors in flat, mountainous and hilly terrain. This equipment is suitable for replacing old conductor wire with a new one.
The main stander is made by customized rectangular steel tubes which are formed by one take art,to avoid any deformation which cause the mechanical parts. The bull-wheel grooves are made up of high resistance interchangeable nylon sectors. Hydraulic power pack to drive 1 drum stand with hydraulic motor. Apart from as a hydraulic cable tensioner, it could be used as puller by its pull back funciton. Working parameters of the machine,in cluding the length of stringing could be seen directly on digital meter counter. Hydraulic front stabiliser. Grounding connection point and temporay anchor point.
Hydraulic Cable Puller-Tensioner,Hydraulic Puller Tensioner,Puller-Tensioner,Stringing Hydraulic Puller-Tensioner
Taizhou Haoxin Electric Power Machine Co., Ltd. , https://www.hxstringingequipments.com